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1

Structures of cytochrome P450 3A4

Emily E. Scott, James R. Halpert

Journal:

Trends in Biochemical Sciences

Year:

2005

Language:

english

File:

PDF, 142 KB

english, 2005

2

Thermodynamics of Ligand Binding to P450 2B4 and P450eryF Studied by Isothermal Titration Calorimetry

Muralidhara, B. K., Halpert, James R.

Journal:

Drug Metabolism Reviews

Year:

2007

Language:

english

File:

PDF, 768 KB

english, 2007

3

Structure–Function Analysis of Human Cytochrome P450 3A4 Using 7-Alkoxycoumarins as Active-Site Probes

Kishore K. Khan, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

2000

Language:

english

File:

PDF, 279 KB

english, 2000

4

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450

M.Danny Burke, Stephanie Thompson, Clifford R. Elcombe, James Halpert, Tapio Haaparanta, Richard T. Mayer

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 1.07 MB

english, 1985

5

Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4

Dmitri R. Davydov, Nadezhda Y. Davydova, Tamara N. Tsalkova, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

2008

Language:

english

File:

PDF, 310 KB

english, 2008

6

Structure-activity relationship of phenoxyaniline congener interactions with cytochrome P450 2B enzymes

Chen, Chao, Liu, Jingbao, Wilderman, P. Ross, Halpert, James R.

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2018

Language:

english

File:

PDF, 48 KB

english, 2018

7

Rat lung and liver cytochrome P-450 isozymes involved in the hydroxylation of m-xylene

Rune Toftgård, Tapio Haaparanta, James Halpert

Journal:

Year:

1986

Language:

english

File:

PDF, 386 KB

english, 1986

8

Variable path length and counter-flow continuous variation methods for the study of the formation of high-affinity complexes by absorbance spectroscopy. An application to the studies of substrate binding in cytochrome P450

Dmitri R. Davydov, Harshica Fernando, James R. Halpert

Journal:

Biophysical Chemistry

Year:

2006

Language:

english

File:

PDF, 432 KB

english, 2006

9

Molecular modeling of cytochrome P450 3A4

Grazyna D. Szklarz, James R. Halpert

Journal:

Journal of Computer-Aided Molecular Design

Year:

1997

Language:

english

File:

PDF, 192 KB

english, 1997

10

Covalent binding of benzo[a]pyrene to cytochrome P-450βNF-B2 and other proteins in reconstituted mixed-function oxidase systems

Cecilia Schelin, Håkan Wallin, James Halpert, Bengt Jergil

Journal:

Chemico-Biological Interactions

Year:

1984

Language:

english

File:

PDF, 1.35 MB

english, 1984

11

Hybrid enzymes for structure-function analysis of cytochrome P-450 2B11

Karen M. Kedzie, Scott W. Grimm, Futai Chen, James R. Halpert

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1993

Language:

english

File:

PDF, 1.05 MB

english, 1993

12

Epoxidation of arachidonic acid as an active-site probe of cytochrome P-450 2B isoforms

Ronald M. Laethem, James R. Halpert, Dennis R. Koop

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1994

Language:

english

File:

PDF, 725 KB

english, 1994

13

Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: The effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium

Dmitri R. Davydov, Elena V. Sineva, Srinivas Sistla, Nadezhda Y. Davydova, Daniel J. Frank, Stephen G. Sligar, James R. Halpert

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2010

Language:

english

File:

PDF, 1.22 MB

english, 2010

14

Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11

Greg R Harlow, You Ai He, James R Halpert

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1997

Language:

english

File:

PDF, 203 KB

english, 1997

15

Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein–ligand interactions based on crystal structures of the ligand-bound enzyme

P. Ross Wilderman, Sean C. Gay, Hyun-Hee Jang, Qinghai Zhang, C. David Stout, James R. Halpert

Journal:

Year:

2012

Language:

english

File:

PDF, 415 KB

english, 2012

16

Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules

Shah, Manish B., Wilderman, P. Ross, Pascual, Jaime, Zhang, Qinghai, Stout, C. David, Halpert, James R.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.90 MB

english, 2012

17

Mutagenesis Study of Asp-290 in Cytochrome P450 2B11 Using a Fusion Protein with Rat NADPH-Cytochrome P450 Reductase

Greg R. Harlow, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

1996

Language:

english

File:

PDF, 148 KB

english, 1996

18

Role of Residue 480 in Substrate Specificity of Cytochrome P450 2B5 and 2B11

Juping Liu, You Ai He, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

1996

Language:

english

File:

PDF, 140 KB

english, 1996

19

Elucidation of Amino Acid Residues Critical for Unique Activities of Rabbit Cytochrome P450 2B5 Using Hybrid Enzymes and Reciprocal Site-Directed Mutagenesis with Rabbit Cytochrome P450 2B4

Grazyna D. Szklarz, You Qun He, Karen M. Kedzie, James R. Halpert, Vicki L. Burnett

Journal:

Archives of Biochemistry and Biophysics

Year:

1996

Language:

english

File:

PDF, 216 KB

english, 1996

20

Interconversion of the Androstenedione Hydroxylase Specificities of Cytochromes P450 2B4 and 2B5 upon Simultaneous Site-Directed Mutagenesis of Four Key Substrate Recognition Residues

You Qun He, Grazyna D. Szklarz, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

1996

Language:

english

File:

PDF, 273 KB

english, 1996

21

Analysis of Four Residues within Substrate Recognition Site 4 of Human Cytochrome P450 3A4: Role in Steroid Hydroxylase Activity and α-Naphthoflavone Stimulation

Tammy L. Domanski, Juping Liu, Greg R. Harlow, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

1998

Language:

english

File:

PDF, 265 KB

english, 1998

22

Structural Determinants of Progesterone Hydroxylation by Cytochrome P450 2B5: The Role of Nonsubstrate Recognition Site Residues

You Qun He, Greg R. Harlow, Grazyna D. Szklarz, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

1998

Language:

english

File:

PDF, 257 KB

english, 1998

23

Cloning and Functional Expression of a First Inducible Avian Cytochrome P450 of the CYP3A Subfamily (CYP3A37)

Jean-Claude Ourlin, Manuel Baader, David Fraser, James R. Halpert, Urs A. Meyer

Journal:

Archives of Biochemistry and Biophysics

Year:

2000

Language:

english

File:

PDF, 324 KB

english, 2000

24

The Importance of SRS-1 Residues in Catalytic Specificity of Human Cytochrome P450 3A4

Fabienne Roussel, Kishore K. Khan, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

2000

Language:

english

File:

PDF, 174 KB

english, 2000

25

Importance of Amino Acid Residue 474 for Substrate Specificity of Canine and Human Cytochrome P450 3A Enzymes

You-Qun He, Fabienne Roussel, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

2001

Language:

english

File:

PDF, 132 KB

english, 2001

26

The Role of Cytochrome 2B1 Substrate Recognition Site Residues 115, 294, 297, 298, and 362 in the Oxidation of Steroids and 7-Alkoxycoumarins

Tammy L. Domanski, You-Qun He, Emily E. Scott, Qinmi Wang, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

2001

Language:

english

File:

PDF, 271 KB

english, 2001

27

A Truncation of 2B Subfamily Cytochromes P450 Yields Increased Expression Levels, Increased Solubility, and Decreased Aggregation While Retaining Function

Emily E. Scott, Margit Spatzenegger, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

2001

Language:

english

File:

PDF, 280 KB

english, 2001

28

Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2′,4,4′,5,5′-hexachlorobiphenyl

David B. Duignan, I.Glenn Sipes, Thomas B. Leonard, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

1987

Language:

english

File:

PDF, 1.58 MB

english, 1987

29

The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P450 PBD-2

David B. Duignan, I.Glenn Sipes, Paul J. Ciaccio, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

1988

Language:

english

File:

PDF, 2.00 MB

english, 1988

30

Selective inactivation by 21-chlorinated steroids of rabbit liver and adrenal microsomal cytochromes P-450 involved in progesterone hydroxylation

James Halpert, John-Yan Jaw, Celia Balfour, Eugene A. Mash, Eric F. Johnson

Journal:

Archives of Biochemistry and Biophysics

Year:

1988

Language:

english

File:

PDF, 965 KB

english, 1988

31

Multiplicity of steroid-inducible cytochromes P-450 in rat liver microsomes

James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

1988

Language:

english

File:

PDF, 1.56 MB

english, 1988

32

Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450IIIA (steroid-inducible) gene subfamily

Paul J. Ciaccio, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

1989

Language:

english

File:

PDF, 1.66 MB

english, 1989

33

cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2′,4,4′,5,5′-hexachlorobiphenyl

Penelope E. Graves, Gasmalla A. Elhag, Paul J. Ciaccio, Don P. Bourque, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

1990

Language:

english

File:

PDF, 1.54 MB

english, 1990

34

Functional expression of mammalian cytochromes P450IIB in the yeast Saccharomyces cerevisiae

Karen M. Kedzie, Richard M. Philpot, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

1991

Language:

english

File:

PDF, 2.17 MB

english, 1991

35

Topological analysis of the active sites of cytochromes P450IIB4 (rabbit), P450IIB10 (mouse), and P450IIB11 (dog) by in situ rearrangement of phenyl-iron complexes

Barbara A. Swanson, James R. Halpert, Lester M. Bornheim, Paul R. Ortiz de Montellano

Journal:

Archives of Biochemistry and Biophysics

Year:

1992

Language:

english

File:

PDF, 558 KB

english, 1992

36

Cytochrome P-450-dependent metabolism of 1,1,2,2-tetrachloroethane to dichloroacetic acid in vitro

James Halpert, Robert A. Neal

Journal:

Biochemical Pharmacology

Year:

1981

Language:

english

File:

PDF, 413 KB

english, 1981

37

The effect of chloramphenicol on the metabolism of 7,12-dimethylbenz[α]-anthracene in rat adrenal and liver microsomes

Birgitta Näslund, Jan Rydström, Margot Bengtsson, James Halpert

Journal:

Biochemical Pharmacology

Year:

1983

Language:

english

File:

PDF, 293 KB

english, 1983

38

Rat lung and liver microsomal cytochrome P-450 isozymes involved in the hydroxylation of n-hexane

Rune Toftgård, Tapio Haaparanta, Lars Eng, James Halpert

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 485 KB

english, 1986

39

Production of superoxide anion radicals during the oxidative metabolism of aminochloramphenicol

Steve Teo, Lance Pohl, James Halpert

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 296 KB

english, 1986

40

Effect of chloramphenicol administration in vivo on cytochrome P-450-dependent monooxygenase activities in liver microsomes from uninduced male rats

James Halpert, Celia Balfour, Laurence S. Kaminsky

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 351 KB

english, 1988

41

Isolation of A non-neurotoxic, non-enzymatic phospholipase a homologue from the venom of the australian tiger snake Notechis scutatus scutatus

James Halpert, David Eaker

Journal:

Year:

1976

Language:

english

File:

PDF, 332 KB

english, 1976

42

Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix

Emily E Scott, Hong Liu, You Qun He, Weihua Li, James R Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

2004

Language:

english

File:

PDF, 727 KB

english, 2004

43

Functional role of residues in the helix B′ region of cytochrome P450 2B1

Wataru Honma, Weihua Li, Hong Liu, Emily E. Scott, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

2005

Language:

english

File:

PDF, 573 KB

english, 2005

44

Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme

Cynthia E. Hernandez, Santosh Kumar, Hong Liu, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

2006

Language:

english

File:

PDF, 566 KB

english, 2006

45

Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide

Ling Sun, Chong S. Chen, David J. Waxman, Hong Liu, James R. Halpert, Santosh Kumar

Journal:

Archives of Biochemistry and Biophysics

Year:

2007

Language:

english

File:

PDF, 467 KB

english, 2007

46

Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W

Harshica Fernando, Dmitri R. Davydov, Christopher C. Chin, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

2007

Language:

english

File:

PDF, 558 KB

english, 2007

47

Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein

Harshica Fernando, James R. Halpert, Dmitri R. Davydov

Journal:

Archives of Biochemistry and Biophysics

Year:

2008

Language:

english

File:

PDF, 537 KB

english, 2008

48

Rational engineering of cytochromes P450 2B6 and 2B11 for enhanced stability: Insights into structural importance of residue 334

Jyothi C. Talakad, P. Ross Wilderman, Dmitri R. Davydov, Santosh Kumar, James R. Halpert

Journal:

Archives of Biochemistry and Biophysics

Year:

2010

Language:

english

File:

PDF, 599 KB

english, 2010

49

Structure–function analysis of cytochromes P450 2B

Yonghong Zhao, James R. Halpert

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2007

Language:

english

File:

PDF, 598 KB

english, 2007

50

Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy

Dmitri R Davydov, James R Halpert, Jean-Paul Renaud, Gaston Hui Bon Hoa

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 312 KB

english, 2003

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